you're not terribly off your game if it's dealt with immediately, but they're fast enough that wise-learned elders like The Mycotyrant can become a huge threat before some decks get going
If youre in a color combination which doesnt traditionally destroy lots of creaturessuch as W/Gyou might think about this one
Pingers These guys are going to hopefully come out early and give us a way to do damage every turn without casting additional spells or throwing them into combat
Card not found is actually just a cantrip, but I included it here because it was a common
Ral, Monsoon Mage /Ral, Leyline Prodigy The spellslinging planeswalker commander Ral, Monsoon Mage is disguised as a coin flip commander, because the card wants to become Ral, Leyline Prodigy which does not care about coin flips
Commander Brimaz, Blight of Oreskos Whenever you cast a Phyrexian creature or artifact creature spell, incubate X, where X is that spell's mana value